KPV Tripeptide

KPV 10mg
KPV is a tripeptide fragment derived from the alpha-melanocyte-stimulating hormone (α-MSH), composed of the amino acids Lysine-Proline-Valine. This sequence is recognized for its potential anti-inflammatory and immunomodulatory activity in experimental models. KPV has been studied for its possible ability to influence gut integrity, inflammatory signaling pathways, and overall epithelial health.

Overview
Research suggests that KPV may interact with melanocortin receptor pathways, which are hypothesized to regulate immune and inflammatory responses. In laboratory models, KPV has been associated with reduced activity of pro-inflammatory cytokines, potentially helping to preserve barrier function in intestinal tissue. This peptide is being investigated for its possible role in modulating responses to inflammatory insults and promoting recovery in conditions linked to epithelial dysfunction.

Beyond gastrointestinal research, KPV has been explored for its potential to mitigate systemic inflammation, oxidative stress, and localized tissue damage, pointing to broader applications across multiple biological systems.

Chemical Makeup

• Molecular Formula: C17H29N5O4
• Molecular Weight: 371.44 g/mol
• Sequence: H-Lys-Pro-Val-OH
• Appearance: White lyophilized powder
• Purity: ≥ 98% (HPLC, batch-certified)

Research and Experimental Findings

KPV and Gut Inflammation
Experimental studies suggest that KPV may attenuate intestinal inflammation by downregulating inflammatory cytokines and enhancing epithelial recovery. Murine colitis models showed improved histological scores and reduced inflammatory infiltration following KPV administration, pointing to its potential relevance in gut mucosal defense.

KPV and Antimicrobial Properties
KPV has been observed to exhibit antimicrobial potential, particularly against bacterial overgrowth in intestinal models. This may involve disrupting microbial adhesion or biofilm formation while simultaneously protecting host epithelial cells.

KPV and Skin Barrier Integrity
Although primarily studied in gastrointestinal contexts, research indicates that KPV may also support epithelial barrier function in skin models, suggesting broader potential applications for mucosal and epithelial repair research.

Storage and Handling

• Store lyophilized peptide at −20°C in a dry environment.
• Reconstitute in sterile water or buffer immediately prior to use.
• After reconstitution, aliquot to avoid repeated freeze-thaw cycles.
  

References

1. Catania A, et al. The neuropeptide alpha-MSH in host defense. Ann N Y Acad Sci. 1999;885:149–170. https://pubmed.ncbi.nlm.nih.gov/10816650/
   
2. Getting SJ. Melanocortin peptides and their receptors: new targets for anti-inflammatory therapy. Trends Pharmacol Sci. 2002;23(10):447–449. https://pubmed.ncbi.nlm.nih.gov/12368067/
   
3. Lipton JM, Catania A. Anti-inflammatory actions of the neuroimmunomodulator alpha-MSH. Immunol Today. 1997;18(4):140–145. https://pubmed.ncbi.nlm.nih.gov/9139458/
   
4. Star RA, et al. Melanocortin peptide therapy of experimental inflammatory bowel disease. Gastroenterology. 1998;114(5):923–932. https://pubmed.ncbi.nlm.nih.gov/9558275/
   
5. Catania A, Lipton JM. Alpha-melanocyte stimulating hormone in the modulation of host reactions. Endocr Rev. 1993;14(5):564–576. https://pubmed.ncbi.nlm.nih.gov/8262000/
   
6. Getting SJ, et al. Melanocortin peptides and their receptors in inflammation and disease. Endocr Metab Immune Disord Drug Targets. 2006;6(3):193–203. https://pubmed.ncbi.nlm.nih.gov/17017852/
   
7. Brzoska T, et al. Melanocortins: multiple actions on skin barrier function. Exp Dermatol. 2008;17(9):793–803. https://pubmed.ncbi.nlm.nih.gov/18476927/
   
8. Ceriani G, et al. The neuropeptide alpha-MSH exerts immunomodulatory and antimicrobial actions in experimental models. Peptides. 2006;27(6):1835–1843. https://pubmed.ncbi.nlm.nih.gov/16386495/
   
9. Catania A, et al. The melanocortin system in control of inflammation. ScientificWorldJournal. 2010;10:1840–1853. https://pubmed.ncbi.nlm.nih.gov/20862381/